Medicinal plants contain some organic compounds which provide definite physiological action on the human body. In the present investigation the antibacterial and antifugal activities of the chloroform and ethanolic extract of leaf and stem of Plumbago capensis L. were studied. Antimicrobial activity was determined by using well diffusion method. The extracts exhibited antimicrobial activities with zones of inhibition ranging from 8 to 16 mm. All the extracts exhibited appreciable activity against all the clinically important bacterial and fungal species clinically investigated. Maximum Inhibition zone (16mm) was observed in stem against P.funicullosum and minimum in leaves (8mm) against E. coli. Primary metamolites screening revealed the presence of carbohydrates, proteins, lipids and phenols in the extracts. The antimicrobial activity of the extract was compared with the standard drugs. The ability of the crude extracts of P.capensis plant parts to inhibit the growth of various bacteria and fungi showed its broad spectrum antimicrobial potential, which may be employed in the management of microbial infections.The aim of study was to evaluate the role of Plumbago capensis extraction on antimicrobial activity. Leaves and stem extracts of this plant showed admirable in vitro activity
