Background: Age-related losses in skeletal muscle mass and function (sarcopenia) present an extremely important current and future public health issue. Aim: to assess leptin level in relation to sarcopenia. Methodology: fifty elderly patients divided into two groups, 25 elderly diagnosed with sarcopenia, and 25 elderly without Sarcopeniarecruited from the Geriatric department, Ain-Shams University Hospital. Leptin level is assessed in each case. Results: sarcopenic patients are significantly older (P≤ 0.05) and have significantly lower physical activity and lower BMI. Leptin is significantly lower in sarcopenic patients in univariate and multivariate regression (P≤ 0.05). Conclusion; Our study showed a negative independent association between leptin and sarcopenia irrelevant to BMI
