Context: Oral squamous cell carcinomas develop from a premalignant lesion or condition which are due to a variety of aetiological factors.
Early identification of these are necessary in order to prevent them from developing into carcinomas which can reduce the mortality and morbidity and improve the quality of life of a person .There are variety of possible aids like histopathology, cytology, histochemistry and Enzyme assays in diagnosing these. However histopathology has many limitations which can be overlooked by an enzyme essay technique.
Keeping this in mind a study was planned to evaluate the association between the serum CPK and oral Leukoplakia.
Aims: Aims and Objectives of the study-
1. To assess the level of CPK in leukoplakic patients and normal subjects.
2. To compare the result
Study design Out patients visiting the department of Oral Medicine and Radiology, Coorg Institute of Dental Sciences, Virajpet in the age range of 30-50 years old males. With smoking habit for more than 5 yrs. 20 subjects were selected and the lesion was subjected to histopathological examination and blood samples were collected and sent for biochemical analysis.
Statistical analysis used: student t test
Mean CPK value of the control group was 96.6 and that of cases was 102.25. Statistical analysis was done using student t test and it was not statistically significant (p=0.441). Correlation between age and CPK value was done and the correlation(r) is -0.083 but it was not significant statistically (p=0.611).
From this study it can be concluded that a definite correlation between CPK enzyme and oral leukoplakia lesions cannot be obtained as it is dependent on different factors like the severity of lesion, grades of dysplasia and invasiveness of lesion.