Endo-perio lesions are common but difficult to diagnose problems. Although most cases resolve following endodontic management, extensive tissue loss calls for the surgical intervention. Currently more and more research is focused on regeneration of dental tissues. Recent advances in regenerative procedures like platelet rich fibrin have made the results of the procedure more predictable. In our case, a 45 year old male patient with endo-perio lesion in right maxillary first molar was treated with platelet rich fibrin and demineralized freeze dried bone graft after conventional endodontic therapy. At the end of 6 months, there was significant radiographic and clinical healing. The novel technique described in the case report will help the clinicians in managing an endo-perio case through regenerative procedures in an efficient way.
