The aim of this study was to investigate the nephroprotective effects of ginger extract against nephrotoxicity induced by lead acetate in male albino rats. Adult 42 healthy male albino rats were divided into 7 groups, each of six rats were used. Lead acetate induced kidney damage showed deleterious histological changes such as significant glomerular and tubular degenerations varying from, glomerular basement thickening, pycnotic nuclei, medullary vascular congestion and moderate to severe necrosis. Treatment with ginger structural organisation of the kidney showed regenerated atropic glomeruli, regeneration of renal tubular epithelial cells and the nuclei are conspicuous centrally located without any vacuolization. It can be concluded that, the lead acetate had adverse effects on the kidney. Ginger showed effective nephroprotective action against lead acetate induced nephrotoxicity in male albino rats.
