Neurobehavioral Alterations In Cadmium Exposed Rats

Research Article
Jyostna V and Sudhakar P
DOI: 
xxx-xxxxx-xxxx
Subject: 
science
KeyWords: 
Open field test, water maze, cadmium, exploratory behaviour, locomotor activity
Abstract: 

A complex network of different interrelated functions working together to manage information is known as memory. Learning and memory engage several processes, including acquisition, consolidation, retention, and recall of information which are mediated by multiple anatomical and neurochemical mechanism systems. This present study was undertaken to examine whether cadmium administration can induce behavioural alterations in male albino rat. Two months old rats were exposed to Cadmium subcutaneously at a concentration of low (2mg/kg bw) and high doses (5mglkg bw) for a period of three weeks. Open field revealed marked impairment in habituation such as rearings, crossings and sniffings in rat exposed to higher doses of Cadmium. Additionally learning and memory assessment during water maze test showed retention in latency, swim speed and swim distance in cadmium exposed rats when compared to the controls. Overall, these results submit that treatment with Cadmium altered behavioural dysfunctions, exploratory behaviour such as head dip duration and head dip counts, locomotor activity and a retention in learning and memory.