Polycystic ovary syndrome (PCOS) is a common endocrine disorder with multiple potential etiologies. Their symptoms are similar to hypothyroidism. The actual etiology of this syndrome is still unclear. The main aim of the study is to analyze the cellular level changes in ovary and thyroid glands in the polycystic induced rats (Rattus norvegicus) and the effect of Pergularia daemia on the treatment of polycystic ovary syndrome. Female albino Wistar rats are used to pursue this study. The polycystic condition is induced in the rats by injecting the male hormone (Testosterone propionate) intraperitoneally. The results shows remarkable changes in the ovaries with the reduced thecal layers and immature graffian follicles in the PCOS condition when compared to normal rats. The Pergularia daemia treated group shows the increased blood vessels size with perfect follicular cells which clearly brings out the management of polycystic ovaries. Histological sections of PCOS rat’s Thyroid gland show high vacuolated areas with less colloidal substances when compared to control and Pergularia daemia group. Thus, the current experiment has proved that the polycystic ovarian syndrome and hypothyroidism show a minor correlated effect in the cellular level and that Pergularia daemia is an effective drug to cure polycystic ovarian syndrome in rats.
