Acculturation process brings challenges (discrimination, language barriers, academics etc.) in a migrant student's life. These challenges lead to acculturation stress, not favourable for their smooth functioning. Previous researches have well documented acculturation across international borders but possibility of negative effects of acculturation stress within national borders, however, have found little or no attention in the psychological literature. Therefore, the present piece of research attempts to assess the level of acculturation stress and address personality constructs that may act as buffer against acculturation stress within national borders. In this study, 200 migrant students (females=118; males=82) participated, age ranged from 20 -25 years. Participants were basically from Southern India (N=84) and North East India (N=116) shifted to Northern region of India for the purpose of higher studies. Results demonstrated more acculturation stress among North East Indians than South Indians. Neuroticism, extraversion, agreeableness, conscientiousness, resilience and universal diverse orientation were significantly related to acculturation stress. Moreover, neuroticism, universal diverse orientation, openness to experience and personal growth initiative significantly predict the possibility of having acculturation stress among migrant students. This research may help psychologists to be informed about possibility of acculturation stress within the country. This study enhances our understanding of personality constructs to buffer against acculturation stress within national borders. It was suggested to adopt effective strategies, introduce psycho-educational programmes and counselling sessions by psychologists/counsellors for smooth functioning of migrant students.