Introduction-Several drugs suffer from the problem of poor absorption or poor bioavailability due to agnimandya or srotoavarodha, hence are unable to give desire effect. Lauha bhasma is one of these drugs, which fails to give uniform results in the management of Hb deficiency. In such consequences there is need of a safe and effective bio availability enhancer. Pippali is one of the bio availability enhancers, which can increase absorption and utilization of lauha bhasma. This clinical trial was thus designed to assess the role of Pippali in enhancing the effect of luaha bhasma on Blood Hb level. Objectives - To evaluate efficacy of pippali as bio availability enhancer of lauha bhasma on blood haemoglobin level in adult healthy volunteers. Material and Method-(i) Design- Open, two arm, randomized and comparative clinical trial (ii) Settings-OPD registered volunteers, Participants-20 Consenting Healthy volunteers(15-60 years of age), of either sex, having Hb between 7-10 gm% in females and 8-12 gm% in males, Intervention-2 groups, Group A - Louha Bhasma 125mg b.d. with water after food and Group B - Pippali 1gm and Louha Bhasma 125mg b.d. with water after food twice a day, Intervention Period - 45 Days, Outcome measures-Blood Hb level. Results-Highly significant results were observed in Group A and Group B. Most effective result - 18.93% improvement in Hb level in Group B as compared to Group A (14.20%). Conclusion-Pippali enhances the efficacy of lauha bhasma in Hb deficiency.
