Thyroid gland is one of the important glands of the endocrine system. Principal function of thyroid gland is to act as a ‘catalyst’ for the maintenance of oxidative metabolism. Hypothyroidism is the most common endocrine disorder observed all over the world in present time. It occurs about 7-8 times more frequently in females than males. In infants, symptoms do not appear till six months because enough hormone is present in mother’s milk. It affects the quality of life of individuals. The only treatment available is synthetic thyroxine tablets which patients had to take life-long. Agni is the unique concept of Ayurveda related to Pachana or conversion, Dhatupaka or Metabolism, etc. i.e. various chemical reactions occurring in the body. It is responsible for and controls each and every process of conversion. The normal as well as abnormal functions of thyroid gland can be correlated to healthy and altered status of Agni. So hypothyroidism can be considered as a stage of Agnimandya resulting in the formation of Ama.. In the bahu dosha avastha of ama, doshavsechana or samsodhana is done which includes expelling out ama by vamana or virechana.