One of the pre-requisites for the success of surgical endodontics relies on selection of root end filing material having beneficial properties such as optimum sealing ability, biocompatibility, good strength, promote healing and radiopacity. Since MTA and Biodentine are the most popularly used root end filling material, MTA has shown superior sealing properties and marginal adaptation and Biodentine showed biocompatibility and the ability to induce odontoblast differentiation. The main aim of this review is to compare sealing ability of root end filling materials. Method: Electronic search of PubMed, Google Scholar, Institutional Library, CTRI, Ind Med, Google and manual search using DPU college library resources. and E-mail to authors revealing information about sealing ability of root end filling material using Scanning Electron Microscope (SEM) and Confocal Laser Scanning Microscope (CLSM).. All cross reference lists of the selected studies were screened for additional papers that could meet the eligibility criteria of the study. Result: Total 94 articles were searched out of which 27 articles were selected after reading title and abstract. As a second step, full text papers were obtained. However studies in which different root end filling materials were used and evaluation of sealing ability was done using scanning electron microscope(SEM) and Confocal Laser Scanning Microscope (CLSM).Finally total 11 articles were included out of which 3 articles were excluded on basis of insufficient data and 8 articles were selected for final synthesis. Conclusion: Biodentine is a better material to prevent apical microleakage and has better marginal adaptation
