Objectives: To evaluate the medication safety with respect to national list of emergency department in tertiary care hospital. Methodology: it was Prospective observational study. This study was conducted in the emergency department Bangalore Baptist hospital. for a period of 6 months from October 2015-march 2016.materials used: patient case sheets, patient medication chart, patient profile form and lab master. The study consisted of: selection of topics. The first step to design a data collection form, second step in the study was prescription analysis, The prescription guidelines, Micromedex, interaction checker, drug interaction. Dose of each drug in prescription was calculated according to body weight. When analysis completed all data entry and result were gained. Result: in this study male patients were listed more 123(55.9%) than the female patients 97(44.1%), and route of administration were listed more in IV(67.2%), presence study showed 70(31.3%)prescription was without generic name,15(6.7%) prescription was not legible, 91(40.8%) prescription had inappropriate abbreviations, prescription had variation of dose {overdose 4(1.8%), under. The study showed more number of moderate interaction 121(55%) as the compared to minor and major interaction, drug interaction between cefotaxime and amikacin was most common drug interaction(20.8%),out of 220 patients 4 (1.8%) of them showed adverse drug reaction. Conclusion: Medication error is the most preventable cuases of complication, life treating and even death. From the study of medication safety in emergency ward found. Prescription pattern of the present study concluded was the most commonly prescribed drug in emergency ward and the most common admition was due to cardiovascular disease. Quality of life seeking changes in the therapeutic approach in general this can be achieved by finding medical and social alternative that have a favourable influence on QoLAs a whole stimulating a better doctor_patient relationship and the development of drug that not only provide treatment efficacy but also beneficial effect on QoL this requires intervention of health professionals to evaluate each case seperately and create an action plan include the withdrawal of guidance and even psychological question for these purpose. Out of 236 patient under study an adverse drug reaction found to be about injection piptaz showed with redness and itching in one patient and one other patient on treatment with local irritation had been observed.
