Background: Atorvastatin (ATV) is a specific competitive inhibitor of 3-hydroxy-2-methyl-glutaryl coenzyme A reductase. Recently, statins have shown pleiotropic effects like antiinflammation and bone stimulation. The aim of the present study was to evaluate the clinical efficacy of subgingivally delivered 1.2% controlled release Atorvastatin gel as an adjunct to scaling and root planing in chronic periodontitis patients. Methods: Thirty-four sites in seventeen patients were categorized into two treatment groups: SRP only (group A) and SRP plus subgingival application of 1.2% Atorvastatin gel (group B). Clinical parameters were recorded at baseline before SRP and at 1 and 3 months; they included plaque index (PI), gingival index (GI) probing pocket depth (PPD), relative attachment level (RAL) Results: Mean probing depth reduction and mean clinical attachment level gain was found to greater in ATV group as compared to group A, at 1 and 3 months.The decrease in GI score at 3 months was greater in group B (1.058±0.300) compared to group A (1.426±0.361). The mean decrease in PPD from baseline to 3 months was 5.235±1.601 and 3.647±1.934 in groups A and B, respectively. Mean RAL gain from baseline to 3 months was7.823±2.455 and 6.647±2.596 in groups A and B, respectively. Conclusion: There was a greater decrease in gingival index and PPD and more RAL gain at sites treated with SRP plus locally delivered ATV in patients with chronic periodontitis
