The one pot reaction between 2-naphthol, aryl aldehydes and ammonia or amines yields aminobenzylnaphthols in process known as Betti reaction. This procedure can be interpreted as extension of the mannich condensation with formaldehyde replaced by aromatic aldehydes, secondary amine by ammonia and the C - H acid by an electron-rich aromatic compound such as 2- naphthol.Betti base derivatives of 2-((4-methylpiperazin-1-yl(phenyl)methyl)benzene-1,3-diol were prepared through reactions of resorcinol, aromatic aldehydes and amines in ratio 1:2:1 in presence of fluoriteat room temperature. The structures of the all synthesized compounds were confirmed by IR, H1 -NMR, and Mass spectral studies. All the synthesized compounds were screened for antibacterial and antifungal activity.
