Background: Renal transplant is one of the treatment options for patients with end-stage renal failure (ESRD) and in the renal transplant process, Human Leukocyte Antigens (HLA) plays an important role. The presence of HLA matching makes the graft survive in the recipient's body and provides a favorable outcome for renal transplant patients. Objective: To see the effect of donor-recipient relationships on HLA matching levels in renal transplant patients in Dr. Kariadi Hospital. Method: This study used an observational study, cross sectional design. This study was conducted in July 2018 through a review of patients' medical records from 2014 to April 2018 at Dr. Kariadi Hospital Semarang. This study involved 23 patients who underwent renal transplant and underwent examination of HLA matching. HLA matching in patients would be assessed based on locus match of HLA-A, HLA-B, HLA-C, HLA-DRB1 and the results of this study were analyzed by a descriptive method. Results: From 23 patients, there were 17 (73.91%) renal transplant patients who had donor-recipient relationships. The number of mismatch in donor-recipients relationship was only 3 (17.65%) out of 17 patients while 14 other patients were full match. Conclusion: The HLA matching in renal transplant patients in Dr. Kariadi Hospital Semarang were closely related to donor-recipient relationship factors.
