Heavy metals always can be found in the fresh waters, brackish waters or marine waters, although in the limited amount. One of highly toxic heavy metals to organism is Plumbum (Pb). The accumulation level of heavy metals in aquatic organism is quick especially that filter feeding in nature. Bivalves groups have been used as indicator organism in determining the pollution in waters. The research aimed at analyzing the heavy metal Pb bio-accumulation in C. javanica in Maros River. The Pb content average at the soft tissue of C. javanica based on the station location successively: Station A (Pappandangan) 6.051±0.064 ppm, Station B (Mannaungan) 2.067±0.024 ppm, Station C 2.326±0.105 ppm, and Station D 0.834±0.261 ppm. The obtained of bio-accumulation factor > 1 about 4.416-13.448. Based on coefficient value, the most dominant influencer for Pb accumulation at gills is water, while at the stomach and organ total is sediment. C. javanica can accumulates the Pb in their body, so the clams can be used as bio-indicator for heavy metal pollution in the river.