Phytochemical screening and antioxidant activities in methanolic extracts of Phyllanthus madraspatensis and Breynia vitis idaea, was carried out. The extracts were subjected to various chemical test for phytochemical constituents, total phenolic contents were evaluated using Folin Ciocalteu method and their antioxidant activity was assayed through (in vitro) radical scavenging activity using DPPH assay, FRAP and reducing power. The phytochemical screening of this study indicated the presence alkaloids, terpenoids, tannis, reducing sugar, saponins, flavonoids, Quinine, protein and steroids in whole plant parts. Results obtained in this investigation indicate that P. madraspatensis extract, rich in phenolics and flavonoids exhibited highest antioxidant. It was observed that the whole plant parts extracts contained high level of phenolic and flavonoid contents that might have accounted for the strong activity observed against DPPH radicals, FRAP and Reducing power. This shows that P. madraspatensis methanolic extract had positive correlation when compared to Breynia vitis idaea methanolic extract may be a potent source of natural antioxidant and its use in the management of diseases associated with oxidative stress is justified.
