Prevalence Of Vitamin D Deficiency And Its Cut Off Level Predicting Adverse Pregnancy Outcome

Research Article
Debasmita Mandal., Biswajit Ghosh., Saroj Mandal., Mriganka Mouli Saha., Smriti Prasad and Abhijit Hazra
DOI: 
xxx-xxxxx-xxxx
Subject: 
science
KeyWords: 
Vitamin D, deficiency, pregnancy induced hypertension, oligohydramnious, Fetal growth restriction, small for gestational age, cut off level.
Abstract: 

Aims &Objectives: Maternal vitamin D deficiency is a major public health problem and can adversely affect pregnancy outcome. We aimed to assess the level of 25(OH) vitamin D in postnatal women within 72 hours of delivery, to find out the correlation of the pregnancy outcome with the level of vitamin D and to calculate the prevalence rate of this ailment. Methods: The study was conducted from 06.06.2012 to 12. 09. 12 in the Department of O&G in collaboration with Rheumatology laboratory of IPGME&R, Kolkata. It is a crossectional observational study. Estimation of 25(OH) vitamin D was done by ELISA method with CPC Euroimmune kit. Results: A total of 143 postnatal women with singleton pregnancy were regarded as subjects after exclusions. Among these 66 (46.15%) had deficiency. Fifty five (38.46%) and 22 (15.38%) women had suboptimal and optimal vitamin D level respectively. We observed the group with deficiency suffered from various adverse pregnancy outcome; oligohydramnios, small gestational age, fetal growth restriction, pregnancy induced hypertension and pre-eclampsia etc. Prevalence rate of vitamin D deficiency was 84%. Cut off level of 25 (OH)D was at ≤ 19.9ng/ml for predicting the adverse outcome. Cord blood estimated and observed to be also vitamin D deficient. Conclusion: Vitamin D deficiency has to be addressed seriously in antenatal mothers. There should be routine estimation of vitamin D in antenatal and postnatal mothers.