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The interest in probiotics and the modulation of the microbiota for restoring and maintaining health have gained a lot of attention over the past decade. Researchers have been keenly investigating the beneficial effects of probiotics on human health and focusing upon the different mechanisms, such as their ability to compete with pathogenic micro organism for adhesion, to antagonize the pathogens, or to modulate the host’s immune response. This has led to a widespread use of probiotics in the management of systemic infections and disease. In the field of periodontics, probiotics have come up as an attractive alternative to antibiotics. They target particular periodontal pathogens, thus increasing the long-term success of periodontal therapy. This review evidence the use of various probiotic strains in periodontal diseases.