Objective: The present study is aim to assess the impact of clinical pharmacist in cardiac unit. Methodology: It was a prospective observational study conducted in cardiac inpatient setting of tertiary care hospital. The newly admitted case was randomly selected on daily basis and reviewed for the potential DDIs and followed up for the assessment of observed drug interaction effect. The data collected in predesigned data collection form for 200 patient of age 65 year and over. The study was conducted for 6 month duration. Result: Out of 200 prescription the mean age of the study population was 71.47 ±6.96 years. The male – female ratio of the study population of 200 cardiac patients, 63.6% were male. Out of 200 prescriptions analyzed, it was found that 265 drug interactions were present. This study showed a median number of 1.33 DDIs in each cardiac patient. The study reveals pharmacokinetic type interaction (56.2 %) and pharmacodynamic interactions (40%), the majority of which was moderate severity (55.4%). Major severity 39.6%.Decreased efficacy in 56 (23.93%) cases followed by bleeding (21.36%).Out of the 265 interventions proposed, the most frequent suggestion was on monitoring for adverse effect (43%) followed by dose adjustment (18%). 26% of interventions were accepted and therapy was changed. The incidence rate of adverse drug reaction was found to be 13.2%. Conclusion: It was concluded that geriatric patient with CVDs are at the higher risk of getting drug- drug interaction related adverse effect and ADR. Which can be avoided by a prior pharmacist intervention.
