Thrombolytic drug have a very great history in saving many lives. They have a wide role in management of disease like ACS, MI, DVT, PE, STROKE etc. Though despite the fact they have proven to be so useful them still holds an upper hand in causality caused by them in history. Thus many studies has been performed to optimize the use of thrombolytic agents and so does new recombinant drug has been introduced since then. This study was performed to find out the various aspects of thrombolytic use and it did put a light on few of the possible factor associated with thrombolytic effects. This study was a Prescription audit which is one of the important component of clinical pharmacy, where clinical pharmacist plays important role in optimization of medication use, minimizing number of medication-related problems and improving medication therapy. The main objective of present study is to find out effect of thrombolytic agent on MI patient. This prospective observational study carried out for a period of 6 months in the Department of Pharmacy practice, Karnataka College of pharmacy, Bangalore Baptist Hospital, Bangalore. The study was conducted on 200 patient receiving thrombolytic Medication. The study showed that the maximum number of patient receiving Thrombolytic medication belongs to age group of 41 to 60 years, while comparing the prevalence of ADR E Alteplase, Streptokinase,Reteplase, Heparin and Enoxaparin respectively was identified which are associated with ADR, The highly prescribed drug was Alteplase , Reteplase and Streptokinase. Evaluation of prescription was performed as it was major factor in identification of drug related ADRs. They study also give an idea of incidence of morbidity and mortality due to thrombolytic treatment. A comparison is done between the treatment procedure and guideline for better understanding of link between the ADRs, Morbidity and mortality ratios.
