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Objective: This study aimed to determine Klebsiella pneumonia antibiotic resistance to different antibiotics. Materials and methods: This is a retrospective study at AlMoujtahd Hospital (Damascus Hospital) between 1/6/2017 and 31/12/2017) including all samples of Klebsiella pneumonia infections during the studied period. Results: We found 63 samples with Klebsiella pneumonia Infection. The most resistance was against Cefaclor (94.4%), while the highest sensitivity against Klebsiella pneumonia was by Imipenem (72.5%). Conclusion: Resistance of the Klebsiella pneumonia in our study to different antibiotics was much higher than the resistance percentages of similar studies and that shows the obvious misuse, overuse and lack of knowledge about their effects among general population.