Scrub typhus is an infectious disease caused by the bacteria Orientiatsutsugamushi from chigger bites. Early diagnosis and treatment may prevent complications including multi-organ dysfunction and death. Many studies have been conducted to analyse the co-relation between clinical characteristics and lab investigations and their effect on outcome; and better prognosis with early initiation of treatment. On reviewing multiple articles, it was observed that the signs and symptomsthat served as independent risk factors for developing severe disease included dyspnoea, altered sensorium, tachypnoea. Elevated liver and renal parameters, albuminuria, Chest X-ray and ABG suggestive of ARDS and CSF analysis suggestive of meningitis were the lab investigations that were observed to be associated with a severe form of the illness.
