The study aimed to demonstrate the seroclearance effect of cupping therapy in patients with hepatitis B virus (HBV) infection. HBV infection is a major health burden; it is often realized at a late stage. Proper assessment and early therapy can suppress replication of HBV preventing the silent progression of chronic liver disease to end- stage cirrhosis. Treatment of chronic hepatitis B (CHB) is directed at suppressing HBV replication before development of any significant irreversible liver cell damage. The long-term goals of CHB therapy are to reduce serum HBV DNA to low or undetectable levels and ultimately reduce or prevent the development of cirrhosis and hepatocellular carcinoma. Complete eradication of HBV is not possible, therefore; the efficacy of treatment is assessed according to the rate of viral seroclearance that can limit long term cirrhosis-related complications. Spontaneous HBV seroclearance in CHB infection occurs at an annual incidence of 1-2%. According to experimental evidences, cupping therapy is a traditional procedure talented for seroclearance or elimination of the undesired elements from the circulation. The study included two healthy volunteers as control and fourteen patients with HBV infection. Two patients were on no therapy and the other twelve patients were divided into three groups according to their medication. The two volunteer patients, the two pre-therapy patients and two patients of each therapy group had undergone three sessions of cupping therapy on the upper back. Revision of results demonstrated that patients have shown low detectable and undetectable levels of HBV after cupping therapy. On conclusion, cupping seroclearnce therapy has got a marked therapeutic effect on hepatitis B viral load.
