Background: squamous cell carcinoma and other premalignant lesions are leading problems in many areas especially saurashtra, Gujarat, India. Tumor cell kinetics can be assessed by many ways but AGNOR counts are more reliable and statistically significant. Objective: The number of AGNOR increases gradually from the normal lining to premalignant and malignant lesions of oral cavity. Materials and Method: This study has been done on biopsy specimen of suspected mass from oral cavity from (2014- 2015) in pathology department of Shri. M. P. Shah. Medical College, Jamnagar. This study includes the age, gender, histological type, grading and AGNOR counting and comparison. Results: On comparing mean AGNOR ± SD of Premalignant(35.1%) 2.53± 0.32with malignant (64.9%) 5.41± 1.40 are statistically significant with p value of 0.001. Conclusion: As AGNOR counts goes on increasing from normal to malignant lesion; chances of malignancy increases. Being simple and cost effective; AGNORcounts can be used routinely in histopathology laboratory as they also help to decide the surgeon the treatment part and prognosis.
