Leptospirosis is a potentially fatal infectious disease which is neglected and very widely prevalent in India causing a major public health problem. The present leptospiral research is focused on Leptospira autumnalis protein damage due to Phyllanthus amarus and Eclipta alba. SDS – PAGE study on Leptospira autumnalis protein damage by both extract treated sample damaged 65 kDa region, a major outer protein (Sphingomyelinase). Interestingly Phyllanthus amarus treated leptospira protein additionally damaged 25 kDa region, inner membrane protein. Protein damage were reported at various levels in Phyllanthus amarus than Eclipta alba. Further in-depth analysis of phytochemical plant compounds against the leptospiral proteins will reduce the side effects produced by synthetic drugs.
