Sjogren’s syndrome commonly known as “Sicca Syndrome” is another representative of long lasting chronic auto-immune disorder primarily affecting exocrine glands such as salivary and lacrimal gland which usually manifest development of lymphocyte infiltration primarily causing destruction of exocrine glands. This is a case of 42 years patient with complaints of difficulty in speaking, development of hoarseness, difficulty in eating, itching of eyes since1 month. Physical Examination revealed tropic ulcers since 2 days, splenomegaly. Ocular signs were confirmed by Schirmer test which revealed <5mm/wetting after 5 minutes. Laboratory investigations revealed detection of anti SS-B antibodies by counter immunoelectrophoresis and Western blotting. Patient was treated with carboxy methyl cellulose-TID, and XyliMelts –BD, lubriderm ointment, amoxicillin and clavulanic acid -625 mg and Prednisolone -5 mg. The main purpose of the author is to make the people well known about the medical field, well acquainted about this disease and its affiliated complications.
