The marketing research models that built for encounter heterogeneous demand, consumer information and human motivation that increasing to purchase of targeted consumers on higher education that influences by message in mix of advertisement and human motivation. The hybrid model was conducted to inquiry with the structural equation modeling and confirmatory strategic research design. The survey was conducted among 127 undergraduates and postgraduates students enrolled in the biostatistics course on higher education in Jakarta. The full hybrid models with the closed fitted models p value ..00, the Root Mean Square Error Approximation value was .12 > .04 and Chi-square/degree of freedom value= 1162.21/402=2.89 < 5. The hypotheses results founded were entire confirmed with t value 3.75 and 4.40 that among t value were more than 2. This research has provided insight on the role of message in mix advertising and high human motivation for increased and pursuit the purchasing of targeted consumers. Hence, these results could be use to help people by guide and inform them to purchases. Future more the research was confirmed the full hybrid model for increasing to purchase of targeted consumers on higher education that influences from message in mix of advertisement and human motivation.
