Objective: To analyze the relationship of socio-demographic, clinical and care aspects changing the quality of life of people with venous ulcers (VU). Method: a Cross-sectional study conducted in a primary health care with 101 people with VU. Data was collected by a structured interview form and the Medical Outcomes Short-Form Health Survey (SF-36). The Friedman test, Mann-Whitney test, and Logistic Regression Binary test were applied. The study was approved by the Research Ethics Committee (CAAE Nº 07556312.0.0000.5537). Results: Socio-demographic, clinical and care variables of greater influence were: age, sleep, intensity and presence of pain, injury time, guidance to regular exercise, guidelines for compression therapy, treatment time and reference and counterreference. The variables sleep, presence and intensity of pain and guidance to exercise influence on the quality of life. Conclusion: Socio-demographic, clinical and care aspects, alone and together, influenced the quality of life of people with VU, especially sleep, pain, exercise guidance, reference, and counter-reference that should be considered in the comprehensive and multidisciplinary nursing care.
