To improve the capacity of the two-phase fluid movement through the horizontal pipes it is necessary to determine as correctly as possible the turbulent drag coefficient, to estimate the associated energetic balance. For modeling was considered the hydrodynamic flow, in turbulent regime. From the analytical known methods are selected the homogeneous, the separated-flow, and the mechanistic models, considered more accurate and suitable for the dedicated applications. This two-phase flow is important in a large variety of applications from engineering, such as natural gas production, oil transportation, drilling, the food processing, polymer processing industry, pharmaceutical domains, etc. The Present paper, is dedicated especially for long pipes of transportation. To better model the reality, is considered the flow between liquid and gas, with different flow rates for each of them. As first step, in laboratory was modified the gas flow rate. For the Reynolds number attached to the flow the range values are from 6000 to 140000. In laboratory were realized around 200 measurements points, tested for each selected models. The analyzed cases allowed the estimation in a proper manner of the accuracy of the drag turbulent factor, by calculating all 10 statistical parameters, for pipes up to 80 cm.
