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Prevention is nothing but the efforts to preclude the cycle of trafficking from ever beginning. Human trafficking being a significant problem of current global scenario, is taking place for the purpose of commercial sexual exploitation although bonded labour is another major purpose. The female victims are subjected to innumerable physical, sexual and psychological tortures, which leaves irreversible scars in the mind and the body for a longer period. In such exploitative form, all types of her rights are denyed where claiming human rights become an expensive factor. Against to general notion that prostitution cannot be prevented as it is an age old practice in Indian society, the study attempted to look into the experience of NGOs regarding possibility of prevention of prostitution in Indian society. A study was conducted in South India to understand preventive intervention of NGOs who do not advocate legalization of prostitution. 24 NGOs were considered for the study. The descriptive and diagnostic research design was adopted along with interview schedule as tool for collecting data. In the process, NGOs agree with the possibilities of prevention of women being in sexually exploitative situation. The study reveals that the adopted preventive programmes are awareness creation among general families, public and sex buyers, institutionalized facilities, organizing SHGs, vocational trainings, framing vigilant committees, counselling, financial support, day care facility for children of CSEW etc. The modes found for outreach programmes are lectures, cultural activities, seminars/workshops, meeting with SHGs, documentary movies, group discussion, training to law implementers, exposure trip etc. Target groups for outreach programmes are youths, students, police, government officials, advocates, general public, exploited women and their children, politicians etc. The study also unveils the optimistic approach of the NGOs, which have gained results towards their goal. They admit the time factor for high rate of success in this path.