Plant-derived phytochemicals have been traditionally used as a natural remedy in the treatment of diverse ailments. They are the backbone of traditional medicine. In this content, there is an interest in developing novel lead molecules from plant sources because of their higher biological activity, safety, and lower cost as compared to the synthetic drugs. So the medicinal plants have a promising role in to prevent and as well as to cure the diseases. Andrographis (Acanthaceae) is a genus of about 40 species, various members of which have a reputation in indigenous medicine. Andrographis echoidies has been used in various folk medicinal preparations and its chemical composition and pharmacological activities have been elaborated recently. However there remains still a huge scope for use of modern scientific methods - genomics, proteomics and bioinformatics in this plant. Bioinformatics shall facilitate analysis and integration of information from these related fields to enable the identification of genes and gene products and elucidate the functional relationships between genotype and observed phenotype. This research report provides a state-ofthe-art overview of bioinformatics study of Andrographis echoidies with emphasis on the current progress and future directions, which shall provide tools and resources necessary to understand and promote advances in this important field. The aim of the present study, 2 proteins of Andrographis echoidies were analysed using bioinformatics tools. Structural prediction and functional characterization of proteins of Andrographis echoidies were done using Expasy Protparm server, 3D structure was done using SWISS MODEL. Plants of different family showing identity 80% and above were selected and its sequences retrieved, aligned using Clustal Omega. phylogenetic tree was constructed for the aligned sequence. Structure prediction showed that α – helix, random coil, β – turn and extended strand predominates. Phylogenetic analysis of Maturase K of Andrographis echoidies reveals that the plants of Verbenaceae, Bignonaceae, and Fabaceae family are closely related. Andrographis echoidies an endangered medicinal plant has to be analysed further for identifying its various medicinal properties.
