Aquaculture is the world worth coming expansion to compensate the shortage of animal protein. Feed in aquaculture plays an important role in the production and feed additive sectors are expanding day after day to achieve better growth. At the same time wide and discriminate use of antibiotics has resulted in serious threat to aqua industry. As an alternative, the probiotic technology provides a solution and proved its success in feeding practices and beneficial effects in disease control and growth of the cultured species. In the present study the effect of the farm isolated lactobacillus species on Antioxidant response, Immune efficiency and disease compatibility of L.vannamei has been investigated. In the first phase of the experimental set up, the shrimp are fed with probiotic supplemented diet for 21 days and in the second phase challenged with WSSV and their response were investigated for 2 days post challenged. The probiotic bacterium Lactobacillus species was added to the formulated basal diet at 5%, 10%and 15% concentration. The treated shrimp group showed significant increase in antioxidant enzyme activity and immunoglobulin substances when compared to control. Both antioxidants and immune efficiency levels are higher in 10% treated shrimp. It is also evident from the investigation that all the three concentrations of the Lactobacillus probiotic bacterium were effective in enhancing the resistance of the shrimp against WSSV.
