Background: There is a need for the development of new diagnostic tests that can detect the presence of active periodontal disease, predict future disease progression and evaluate the response to periodontal therapy. Aim: To study gingival crevicular fluid level of soluble triggering receptor expressed on myeloid cells-1 as per periodontal health status. Methods: Thirty subjects were divided in three groups as per periodontal health status: healthy (Group A), gingivitis (Group B) or chronic periodontitis (Group C). Plaque Index (PI), Gingival Index (GI), Probing pocket depth (PPD) and Clinical attachment level (CAL) were recorded Results: At baseline, the mean sTREM-1 levels in group A, group B and group C were 68.1±2.2 pg/ml, 263.14±80.3 pg/ml and 3664.3 ±13135.4 pg/ml respectively. A reduction was seen from baseline to 8 weeks in group B and group C, with mean sTREM-1 level in group B and group C of 115.98±36.04 pg/ml and 228.07±102.76 pg/ml respectively. A positive correlation between GCF levels of sTREM-1 and Plaque Index (PI), Gingival Index (GI), Probing pocket depth (PPD) and Clinical attachment level (CAL) was also observed. Conclusion: sTREM-1 were observed in periodontitis patients. It may act as inflammatory biomarker of periodontal disease and can be useful both as a diagnostic biomarker and predictor of future disease initiation and progression.
