Attempt to building block approach, and synthesized fluorine containing organic halo substituents into imidazole and 1, 2, 4-triazole heterocyclic ring via metathesis. Imidazole (A) and 1, 2, 4-Triazole (B) were reacted with fluorine containing halo (chloride/bromide) benzyl compounds (1-10) in the presence of triethylamine in benzene at reflux temperature for 24 hrs to form corresponding fluorine containing imidazole (11-15) and 1, 2, 4-triazole (16-20) derivatives in ~60% yields. The derivatives of Imidazole and 1, 2, 4-Triazole are stable and soluble in CHCl3, CH3CN, CH2Cl2, THF and DMSO. These compounds have been characterised by using IR, 1 H and 19F NMR spectroscopy, MS and elemental analysis. These derivatives (11-20) of Imidazole and 1, 2, 4-Triazole have been found bio-active.
