Objective PEGylation (polymeric substance) is clinically proven and attract both scientific and commercial interests, here we emphasize the overcome the drawback of solution phase methods, the five membered ring, imidazolone moiety is present in a wide range of naturally occurring molecules, for example furan is a five membered heterocyclic nucleus which contain oxygen atom as heteroatom having a broad spectrum of biological activity and here we attempt PEG lated product, involved free carbonyl terminal was used for conjugation via condensation. The solid matrix characterized by spectral studies and their biological activity. Result we prepared a series of PEGlyted 3-(4-Acetyl-phenyl)-5-aryldine-2-furan-2-yl-3,5-dihydro[1]imidazol-4-one with different aldehydes through Erlenmeyer reaction and condensation methods by using PEG-aldehyde. These newly synthesized compounds were characterized by IR, 1HNMR, MASS, SEM, DLS studies. All final compounds are screened for their antioxidant, anti[1]inflammatory activities done through by DPPH, Nitric oxide radical scavenging, ferrous ion chelating and hemolytic assay. Conclusion furan based compounds having imidazolone moiety having greater importance in medicinal chemistry. In this work we attempt to highlight those compounds which show good potential against Biological activity. Of all the compounds 4c, showed to be a potent molecule
