Management of type-II diabetes mellitus (T2DM) includes the removal of glucose in blood by stimulating the glucose uptake into peripheral tissues. In relation to DM, recent researchers have demonstrated the beneficial effects of flavonoids, this study was designed to examine the effects of chrysin, a flavone, on glucose uptake into L6 muscle cell line, and to investigate the molecular mechanisms involved in glucose uptake through the expression studies of GLUT4 and PPARγ using L6 cell lines. The cytotoxicity was also evaluated by MTT assay. The results revealed that the chrysin showed the minimal cytotoxicity and the better glucose uptake potential by cell lines over control. The gene expression studies strongly evidenced that the chrysin activates PPARγ thereby increasing the expression of glucose transporter GLUT4.
