Gandusha is clinically effective in the management of periodontal disease. This study is an in-vitro analysis on determining the antimicrobial efficacy of the drug using standard Antimicrobial Sensitivity Test against a fungal culture isolated from a patient. The test was performed according to the Well diffusion method having 6 mm diameter wells on Sabouraud Dextrose Agar (SDA). Each well was loaded with the test drug mixed in 20 μl of sterile distilled water and fluconazole 2.5 mg / ml was used as the positive control. According to the results the test drug showed Inhibitory Zone Diameter (IZD) of 15 mm. Therefore it can be stated that the test drug is more effective than the positive control and the isolated culture is sensitive to the test drug as it had shown a IZD of 19 mm while it is intermediate sensitive for the positive control as 15 mm comes under Intermediate Sensitive range (15 – 18 mm). These results support the fact that the indigenous mouth wash (Gandusha) is effective in the management of periodontal disease.
