Introduction: Zenker's diverticulum (DZ) is a relatively rare clinical condition, with a total estimated prevalence of around 0.11%. In relation to the development mechanism and the characteristics of the enlarged space, it is easy to understand how these diverticular sacs usually, do not contract adherence to the surrounding structures. However, occasional occasional inflammatory processes can sometimes be fixed to varying degrees and by extensions. The purpose of this study is to evaluate in the light of new technologies the most appropriate treatment for such a condition in relation to age and clinical conditions of the patient. Materials and Methods: From January 2017 to November 2017, at the AUO outpatient clinic of the University of Catania, there were observed 2 cases involving Zenker diverticulum (DZ) patients were male with an average age of 52 years (range 54-50). Symptomatology in the first period was mute or consisted of vague and intermittent foreign body sensations and swallowing disorders, symptoms often considered by the patient and the doctor such as those due to a trivial pharyngitis Results: through a left cervical incision ( crico pharyngeal muscle myotomy with or without the diverticulum resection, or (in the other patient) by endoscopically dissecting the septum between the diverticular pocket and the esophageal lumen, in which the fibers of the SES grow. Spongy fibers covering a length of about 2.5- 3 cm of the esophageal wall. Discussion: In asymptomatic or minimal symptomatic diverticies no need for treatment. In patients with oesophageal diverticulas, where dysphagia is related to alteration of basic motility, therapy should be directed to cure this disorder. The esophageal diverticulus reaches considerable size, or if it is associated with a sin dentistry, it is possible to evaluate the possibility of surgical removal (resection). Conclusions: Open surgery allows to definitively resolve stenosis, with clinical and radiological remission of the disease, technological progress and the introduction of less invasive treatments for the patient, allowing the treatment of the Zenker diverticulum with flexible endoscope that can be proposed in all symptomatic patients with severe comorbidities for good clinical results. Obtained