Concentrations of adrenomedullin (ADM) in circulation enhances during pregnancy. The pattern of ADM level and gene expression of ADM, its receptor components from early pregnancy has been studied in our present work. Calcitonin gene-related peptide (CGRP) and its related peptide, adrenomedullin (ADM), have vasorelaxant activity in a variety of tissues. The CGRP plays an important role in maintaining uterine relaxation during pregnancy. A healthy pregnancy requires strict coordination of genetic, physiologic, and environmental factors. The relatively common incidence of infertility and pregnancy complications has resulted in increased interest in understanding the mechanisms that underlie normal versus abnormal pregnancy. The peptide hormone adrenomedullin has recently been the focus of some exciting breakthroughs in the pregnancy field. Adrenomedullin (ADM) is a 52-amino acid peptide with structural homology to calcitonin gene-related peptide (CGRP) initially isolated from human pheochromocytoma. Hence, in the present study, the AM-antagonist AM22-52 is continuously infused through osmotic mimipumps during 2–8 days of gestation. On the 9th day, we assessed the weights of uteroimplantation site to know the growth of uterus and implantation tissues. Later we examined apoptotic changes in uteroimplantation site by Haematoxylin and eosin staining
