This study was carried out with an objective to investigate the antibacterial activity and phytochemical screening of the aqueous and methanol extracts of aerial part of Ipomoea aquatica Forsk. The antibacterial activity of the different extracts of Ipomoea aquatica were evaluated by disc diffusion method against three ATCC bacterial species. Zone of inhibition of the plant extracts were compared with ciprofloxacin and ampicillin standard discs. The presence of tannins, flavonoids, saponins, amino acids, steroid, etc in the different extracts were established. The methanol extract was effective against ATCC strains of Staphylococcus aureus whereas aqueous extract wasn’t effective against ATCC strains of Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. The results suggested that aerial part of Ipomoea aquatica is effective against gram positive bacteria.