Microbial disease are Infectious and one of the major problems in developing as well as developed countries. Traditional medicinal plants are widely used to treat the microbial diseases due to their rich source of antimicrobial activity and less cost. The different plant parts such as seed, fruit, root, bark, stem, leaf and even the whole plant were used to treat various microbial disease. There are considerable alternative sources of natural antimicrobials from plants with different mode of actions. Some of them are employed in traditional medicine for centuries and effective one. This review provides the potency of plants as alternative source for antimicrobials and a lucid data of nearly 18 traditional medicinal plants with antimicrobial activity and this would open up the scope for further analysis of medicinal plant extracts to develop effective antimicrobial drugs.