The present study aims to establish a positive correlation between the endogenous glutathione content and hepatoprotective activity, of the aqueous extract (AE) of Chaetomorpha linum. Presence of higher amounts of glutathione is indicative of the higher antioxidant potential of the extract. 20 female wistar strain rats were divided into four groups, with 5 animals each. Group 1 served as control, group 2 was treated with carbon tetrachloride, which is a potent and established model of hepatotoxicity. Group 3 animals were fed with 100 mg / kg body weight (aqueous extract) of C. linum. Group 4 animals were fed with the same dose of AE as that of group 3, followed by carbon tetrachloride treatment. Endogenous glutathione and protein contents of the macro algae were estimated. Tissue peroxidation levels and glutathione activity were assayed in the liver tissues of the experimental animals in vivo
