The Health Belief Model has been one of the most widely used conceptual frameworks in health behaviour. The HBM has been used both to explain change and maintenance of health -related behaviours and as a guiding framework for health behaviour intervention. A school-based prospective interventional study (pre – post) was conducted. So as to apply the Health Belief Model Guides for the health education intervention to promote breast self-examination among female students’. The target population is the female students in higher secondary schools, six schools were selected randomly. A sample of 320 female students from intervention schools and 320 female students from comparison schools was included. Data was collected using a questionnaire, and analyzed using SPSS and the relationship between the variable was checked using X2 -Test at the level of significance (0.005). The overall knowledge of breast cancer among the female students increased from 31.9% to 99.7% after the intervention. The statistic showed significant results in both intervention and comparison schools (p=0.005). The knowledge among female students regarding the susceptibility to breast cancer was 39.2% before intervention which increases to 95.4% after the intervention among female students. The statistic showed significant results (p=0.005). The statistic showed the significant result (p=0.005). There was no significant relation in the comparison schools.64.3% of female students had no appropriate place to practice breast selfexamination. This increased to reach (75.1%) after the intervention, which is a significant positive change in their knowledge (P=0.005). The study recommended the Intensive health education program needs to be implemented to raise female students awareness about breast cancer and breast self-examination in comparison schools.
