Addiction is a chronic brain disease which include craving and relapsing response characterized by compulsive substance/drug seeking for use in despite of harmful. Addictive substance has high tendency for long lasting changes in the structure, function and working property of the brain leading to harmful and bizarre behaviours. Globally, it was accounted as an economic burden through early morbidity, crime and treatment cost. The present study was designed to assess the antiaddictive property of L-tetrahydropalmatine (l-THP) (20mg/kg; 10mg/kg and 3mg/kg, p.o.) on Apomorphine induced addiction (1mg/kg/ml, i.p.) rats models using- Condition Place Preference (CPP) and Drug self-administration (DSP) methods for anti-addictive study; Runway selfadministration test (RST) and Elevated plus maze (EPM) methods for anti-craving activity and Cueinduced relapse method for anti-relapsing property. l-THP was found to be significantly (p0.05) decreased the no. of entries and time spent in light compartment on re-exposure to CPP model for anti-relapsing study. There was a significant increase in brain Dopamine (DA) level with positive control group but also significantly decrease of DA level with treatment group. All these may be attributed to the property of l-THP as a DA receptor antagonist against Apomorphine- a DA receptor agonist. Hence, can be considered as effective antiaddictive drug in the treatment of addiction.
