In India diabetes mellitus prevalence ranges from 0.4 to 3.9% in rural areas and from 9.3 to 16.6% in urban areas. Serum uric acid has been shown to be associated with oxidative stress and production of tumor necrosis factor-α [2], which are both related to the development of diabetes. Uric acid levels were measured in both, serum and urine samples, and then urine/serum ratio of uric acid levels was calculated and compared between Type 2 diabetic patients and control subjects. Our results demonstrated a profound increase in uric acid urine/serum ratios in Type 2 diabetic patients as compared to healthy controls.Our data demonstrated significant positive correlation between Urine and serum uric acidand serum glucose levels in patients diagnosed with Type 2 diabetes. Our results demonstrated no effect of sex on uric acid levels in serum and urine in both control and diabetic patients. Body mass index had a significant and independent impact on plasma uric acid levels both in non-diabetic and diabetic men and women. This prospective study suggests a positive association between the plasma concentration of uric acid and the incidence of type 2 diabetes. The uric acid may serve as a potential biomarker of deterioration of glucose metabolism.
