Immune activation is an effective and protective approach against emerging infectious diseases. The immunomodulatory activities of Shorea robusta bark was evaluated by testing the various immunological parameters. Sheep red blood cells (5 x 109 cells/ml) were used for immunizing the animals that belongs to immunized groups. This study was performed with a set of immunomodulation such as the humoral antibody response (hemagglutination antibody titers, immunoglobulins), cell mediated immune response (delayed type hypersensitivity and phagocytosis), nitroblue tetrazolium (NBT) reduction test, total lymphocyte count (TLC) and DC. Ethanolic extract of Shorea robusta bark was administered p.o. (orally) to the mice at a dose of 100mg and 300mg/kg body weight per day for 14 days. In this study, Shorea robusta bark extract administrated rat models at 300mg/kg per day, i.p should significant important in stimulating immunomodulatory response, thus Shorea robusta bark is an effective natural health product for in modulating immune system.
