The rice we evil, Sitophilus oryzae is one of the major pests of stored grains. This study investigates the bio efficacy of the Glycosmis pentaphylla in controlling infestations of the rice weevil. Different doses of aqueous, ethanolic and acetone extracts of the leaves of the plant Glycosmis pentaphylla were checked and the results showed that high doses of the extracts were significantly more toxic to Sitophilus oryzae(L.) compared to lower doses. The efficacy of the extracts on the insects was dosedependent. LD50 value was assessed. In the present investigation, acetone extracts of Glycosmis pentaphylla have shown very high toxicity to Sitophilus oryzae Linn. After the extract exposure of the plant, enzyme activity-digestive enzyme-amylase and protease, lactic dehydrogenase, Lipid, Nuclease and catalase of the insects were checked. Enzyme activity was found to be depleted compared to control. Acetone extracts of Glycosmis pentaphylla have exerted toxic effects on enzymatic parameters of Sitophilus oryzae, it proved to have strong insecticidal activity, So it could be integrated into pest management system.
