Sepsis is a universally prevalent condition in patients that carries a major risk of morbidity and mortality. Early identification recognition of sepsis as the cause of deterioration is desirable desired, so effective treatment active management can be initiated commenced rapidly quickly. Traditionally Conventionally, diagnosis was based established on presence existence of two or more positive affirmative SIRS criteria due to infection sepsis. However Nevertheless, recently recently published issued sepsis-3 criteria put more emphasis prominence on organ dysfunction caused triggered by infection in the definition of sepsis Physicians Clinicians still rely depend on a number of traditional and novel innovative biomarkers to discriminate classify infected and non-infected patients between patients with and without infection, as the cause of deterioration. The aim objective of this review is to focus emphasis on the various numerous biomarkers available. To conclude Procalcitonin, presepsin, CD64, su PAR, and sTREM-1 are the best evaluated biomarkers for diagnosis and prognostication of sepsis to date.(1)It is important significant to test utility efficacy, performance ,and validity strength of future biomarkers before implementing employing them in routine clinical medical care
