Background: Diabetes mellitus poses a serious health challenge worldwide and there has been an increased awareness for self-monitoring and point of care testing. There are different methods to determine blood glucose levels and glucometers have been of help to improve turn-around time. Comparison of glucose result by spectrophotometer method and glucometer was done in this study. Materials and Methods: 200 subjects male and female ages 20 and above were tested using methods involvingglucometer and spectrophotometer. Result: 185(92.5%) has glucose level (random blood sugar) within normal range,15(7.5%) above normal range by spectrophotometer while 180 (90.0%) showed glucose level within normal range and 20(10.0%) above normal range by glucometer using Normal range as 3.5-11.0mMol/L. Statistical comparison of blood glucose result by the two methods using students’t-test showed significant difference (P<0.05). Correlation analysis of the two methods shows strong correlation which is significant at P<0.01. Conclusion: The study established the fact that there is a significant difference between blood glucose result obtained from spectrometric method and glucometer but there is a strong correlation in glucose estimation.
